Clustering and signalling of cell receptors
نویسندگان
چکیده
منابع مشابه
Clustering and Signalling of Cell Receptors
As a response to ligand binding, transmembrane cell receptors often enhance their clustering, or oligomerization, during the signalling process. Here we present a statistical mechanical model which combines the aspects of clustering and signalling. In this model, receptors float on the surface, while for two neighboring receptors, there is an interaction energy dependent on their conformational...
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We present a model of cooperativity between transmembrane receptors. Two responses to ligand binding, receptor signalling and the enhancement of clustering, or oligomerization, are unified in the same framework. The model is based on a conformation-dependent interaction between neighboring receptors. In order to decrease the total energy of the system, neighboring receptors tend to have a same ...
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ژورنال
عنوان ژورنال: Physica A: Statistical Mechanics and its Applications
سال: 2002
ISSN: 0378-4371
DOI: 10.1016/s0378-4371(02)00834-8